Stable Polymorph of Venlafaxine Hydrochloride by Solid-to-Solid Phase Transition at High Temperature
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- 作者：Saikat Roy ; Prashant M. Bhatt ; Ashwini Nangia ; Gert J. Kruger
- 刊名：Crystal Growth & Design
- 出版年：2007
- 出版时间：March 2007
- 年：2007
- 卷：7
- 期：3
- 页码：476 - 480
- 全文大小：423K
- 年卷期：v.7,no.3(March 2007)
- ISSN：1528-7505
文摘
A novel polymorph of the antidepressant drug venlafaxine hydrochloride (VenHCl) was visualized in thermal microscopyand identified by variable-temperature powder X-ray diffraction at 180-190 
C. Its single-crystal X-ray structure was solved and refinedsatisfactorily in P21/n space group (form 6, Z' = 2, T = 100 K, R1 = 0.1073). The powder X-ray diffraction pattern and melting point ofform 6 are significantly different from the known polymorphs 1-5. Form 6 has a higher melting point and is more stable than marketeddrug forms 1 and 2.
C. Its single-crystal X-ray structure was solved and refinedsatisfactorily in P21/n space group (form 6, Z' = 2, T = 100 K, R1 = 0.1073). The powder X-ray diffraction pattern and melting point ofform 6 are significantly different from the known polymorphs 1-5. Form 6 has a higher melting point and is more stable than marketeddrug forms 1 and 2.