Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine

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• 作者：Prashant M. Bhatt ; Yasser Azim ; Tejender S. Thakur ; Gautam R. Desiraju
• 刊名：Crystal Growth & Design
• 出版年：2009
• 出版时间：February 4, 2009
• 年：2009
• 卷：9
• 期：2
• 页码：951-957
• 全文大小：283K
• 年卷期：v.9,no.2(February 4, 2009)
• ISSN：1528-7505

文摘

Co-crystal forming abilities of the two anti-HIV drugs lamivudine and zidovudine were studied. A study of five crystal structures was carried out to investigate the general applicability of the retrosynthetic approach in the design of new co-crystals. This analysis of co-crystals and salt structures showed a complete to partial success, and in one case, a total failure to obtain the predicted synthon. Both screening strategies and retrosynthetic methods may be appropriate for the discovery of new active pharmaceutical ingredients co-crystals.