Unprecedented Bridged Annulation Approach to the Construction of 5,6-Dihydro-4H-benzo[kl]acridines

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• 作者：Atul Goel ; Salil Pratap Singh ; Amit Kumar ; Ruchir Kant ; Prakas R. Maulik
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：November 19, 2009
• 年：2009
• 卷：11
• 期：22
• 页码：5122-5125
• 全文大小：215K
• 年卷期：v.11,no.22(November 19, 2009)
• ISSN：1523-7052

文摘

A general and novel “bridged annulation” methodology for the synthesis of 5,6-dihydro-4H-benzo[kl]acridines has been developed via Michael addition of a conjugate base of 9-methyl-3,4-dihydroacridin-1(2H)-one to various cyclic or acyclic α,β-unsaturated carbonyl/nitrile compounds under mild conditions at room temperature in a short time. To the best of our knowledge, such a general bridged annulation for the synthesis of fused N-heterocycles has not been reported in the literature.