Chemical Engineering of Mesenchymal Stem Cells to Induce a Cell Rolling Response

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• 作者：Debanjan Sarkar ; Praveen Kumar Vemula ; Grace S. L. Teo ; Dawn Spelke ; Rohit Karnik ; Le Y. Wee ; Jeffrey M. Karp
• 刊名：Bioconjugate Chemistry
• 出版年：2008
• 出版时间：November 19, 2008
• 年：2008
• 卷：19
• 期：11
• 页码：2105-2109
• 全文大小：233K
• 年卷期：v.19,no.11(November 19, 2008)
• ISSN：1520-4812

文摘

Covalently conjugated sialyl Lewis X (SLeX) on the mesenchymal stem cell (MSC) surface through a biotin−streptavidin bridge imparts leukocyte-like rolling characteristics without altering the cell phenotype and the multilineage differentiation potential. We demonstrate that the conjugation of SLeX on the MSC surface is stable, versatile, and induces a robust rolling response on P-selectin coated substrates. These results indicate the potential to increase the targeting efficiency of any cell type to specific tissue.