Enantioselective Synthesis of Pladienolide B and Truncated Analogues as New Anticancer Agents

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• 作者：Vemula Praveen Kumar ; Srivari Chandrasekhar
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 19, 2013
• 年：2013
• 卷：15
• 期：14
• 页码：3610-3613
• 全文大小：323K
• 年卷期：v.15,no.14(July 19, 2013)
• ISSN：1523-7052

文摘

An enantioselective synthesis of natural anticancer macrolide pladienolide B is described. The synthetic highlights include Sharpless asymmetric epoxidation, ring closing metathesis (RCM), Ireland鈥揅laisen rearrangement, Shi epoxidation, and Pd-catalyzed Stille coupling as key steps. The synthetic route also allowed the synthesis of the truncated analogues (41a鈥?b>d) of pladienolide B.