Spiroiminodihydantoin as an Oxo-Atom Transfer Product of 8-Oxo-2'-deoxyguanosine Oxidation by Chromium(V)

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• 作者：Peter G. Slade ; Nigel D. Priestley ; Kent D. Sugden
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：October 25, 2007
• 年：2007
• 卷：9
• 期：22
• 页码：4411 - 4414
• 全文大小：108K
• 年卷期：v.9,no.22(October 25, 2007)
• ISSN：1523-7052

文摘

D=ol701667tn00001>Oxidation of the DNA lesion 8-oxo-2'-deoxyguanosine by the two electron oxidants N,N'-ethylenebis(salicylideneanimato)oxochromium(V) (Cr(V)-salen) and bis(2-ethyl-2-hydroxybutyrato)oxochromium(V) (Cr(V)-ehba) at neutral pH forms spiroiminodihydantoin by an oxo-atom transfermechanism. The chromium complexes are models of a DNA oxidation pathway caused by the carcinogen chromate.