Disruption of Sexual Differentiation in Genetic Male Common Carp (Cyprinus carpio) Exposed to an Alkylphenol during Different Life Stages

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• 作者：Sylvia Gimeno ; Hans Komen ; Paul W. M. Venderbosch ; and Tim Bowmer
• 刊名：Environmental Science & Technology
• 出版年：1997
• 出版时间：October 1997
• 年：1997
• 卷：31
• 期：10
• 页码：2884 - 2890
• 全文大小：242K
• 年卷期：v.31,no.10(October 1997)
• ISSN：1520-5851

文摘

A genetically male population of the common carp,Cyprinuscarpio, was exposed to a measured concentration of0.14mg/L 4-tert-pentylphenol (TPP) for various periodsbeforeand during sexual differentiation in order to determinethepresence of a labile period for endocrine disruption.Exposure to TPP for 3 days during the embryo-larvalperioddid not affect the process of sexual differentiation northe proliferation of the primordial germ cells.Longerexposures, starting before and including sexual differentiation, induced the formation of an oviduct. Theoviductwas incomplete or completely closed depending on thetiming of the exposure. Once present, this featurewaspersistent in individuals that were returned to cleanwaterfor 59 days. Exposures for various durations before orduringsexual differentiation reduced significantly the numberof primordial germ cells in a dose-related mannerirrespectivelyof the timing of the exposure. These resultsdemonstratethat the oviduct is a permanent feature that can be usedas an end point in a test with male fish for detectingestrogenicity. In addition, they reveal that the periodpriorto sexual differentiation (24-51 days post hatch) is,besidesthe period sexual differentiation itself (50-110 days posthatch),sensitive to endocrine disruption, meaning that thedurationof exposure of such a test could be reduced to a morenarrow labile period.