Recognition of Hg2+ Ion through Restricted Imine Isomerization: Crystallographic Evidence and Imaging in Live Cells

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• 作者：Amal Kumar Mandal ; Moorthy Suresh ; Priyadip Das ; E. Suresh ; Mithu Baidya ; Sudip K. Ghosh ; Amitava Das
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：June 15, 2012
• 年：2012
• 卷：14
• 期：12
• 页码：2980-2983
• 全文大小：233K
• 年卷期：v.14,no.12(June 15, 2012)
• ISSN：1523-7052

文摘

A newly synthesized imine-based receptor (L) showed remarkable specificity toward the Hg²⁺ ion in aqueous media over other metal ions. Coordination of L to Hg²⁺ induces a turn-on fluorescence response. This was explained based on the restricted imine isomerization along with PET on coordination to Hg²⁺. X-ray structural evidence tends to favor a C鈥揅 bond rotation rather than C鈺怤 isomerization for adopting a favorable conformation in L for coordination to Hg²⁺. This reagent could be used for imaging the accumulation of Hg²⁺ ions in HeLa cells.