Peanut is a potent plant to be induced to synthesize bioactive stilbenoids. Bioactivities of thosestilbenoids except resveratrol have been meagerly investigated. When peanut kernels (Tainan 14, aSpanish cultivar) were imbibed, incubated 3 days for germination, sliced, incubated with artificialaeration, periodically sampled, lyophilized, extracted with methanol, and subjected to reverse-phaseHPLC analysis, four major fractionations were detected and identified as
trans-resveratrol (Res),
trans-arachidin-1 (Ara-1),
trans-arachidin-3 (Ara-3), and
trans-isopentadienylresveratrol (IPD). Duringincubation of the peanut slices, contents of Res, Ara-1, and Ara-3 increased tremendously from initiallytrace or not detectable amounts up to 147.3, 495.7, and 2414.8
![](/images/entities/mgr.gif)
g/g, corresponding to 20, 16, an
d24 h of incubation, while IPD contents continued to increase up to 28 h (4474.4
![](/images/entities/mgr.gif)
g/g). When the fourstilbenoids and butylated hydroxytoluene (BHT) were subjected to antioxidant characterization byvarious measures, all have exhibited varied potencies of antioxidant activity. In particular, retardationof absorbance increase at 234 nm as formation of the conjugated diene hydroperoxides in a realpork oil system stored at 60
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C, supplement of Ara-1 at 100
![](/images/entities/mgr.gif)
M has shown equivalent or even greateractivity than did BHT. When the media were supplemented with Res, Ara-1, Ara-3, and IPD at 15
![](/images/entities/mgr.gif)
Mfor cultivation of mouse macrophage RAW 264.7 cells activated by lipopolysaccharide (LPS), theLPS-induced extracellular production of
prostaglandin E2 (PGE
2) and nitric oxide (NO) was significantlyinhibited by Ara-1 (
p < 0.001), Res (
p < 0.001), Ara-3 (
p < 0.01), and IPD (
p < 0.01). It is noteworthyand of merit that all test stilbenoids have exhibited potent antioxidant and anti-inflammatory activitiesand varied as affected by number of hydroxyl groups and isopentenyl or isopentadienyl moiety.