HIV Capsid Assembly, Mechanism, and Structure

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• 作者：Bo Chen
• 刊名：Biochemistry
• 出版年：2016
• 出版时间：May 10, 2016
• 年：2016
• 卷：55
• 期：18
• 页码：2539-2552
• 全文大小：786K
• 年卷期：0
• ISSN：1520-4995

文摘

The HIV genome materials are encaged by a proteinaceous shell called the capsid, constructed from ∼1000–1500 copies of the capsid proteins. Because its stability and integrity are critical to the normal life cycle and infectivity of the virus, the HIV capsid is a promising antiviral drug target. In this paper, we review the studies shaping our understanding of the structure and dynamics of the capsid proteins and various forms of their assemblies, as well as the assembly mechanism.