Antibacterial Neurymenolides from the Fijian Red Alga Neurymenia fraxinifolia
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- 作者：E. Paige Stout ; Adam P. Hasemeyer ; Amy L. Lane ; Theresa M. Davenport ; Sebastian Engel ; Mark E. Hay ; Craig R. Fairchild ; Jacques Prudhomme ; Karine Le Roch ; William Aalbersberg ; Julia Kubanek
- 刊名：Organic Letters
- 出版年：2009
- 出版时间：January 1, 2009
- 年：2009
- 卷：11
- 期：1
- 页码：225-228
- 全文大小：119K
- 年卷期：v.11,no.1(January 1, 2009)
- ISSN：1523-7052
文摘
Two novel α-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of α-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the α-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).