Callophycoic Acids and Callophycols from the Fijian Red Alga Callophycus serratus

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• 作者：Amy L. Lane ; Elizabeth P. Stout ; Mark E. Hay ; Anne C. Prusak ; Kenneth Hardcastle ; Craig R. Fairchild ; Scott G. Franzblau ; Karine Le Roch ; Jacques Prudhomme ; William Aalbersberg ; Julia Kubanek
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：September 14, 2007
• 年：2007
• 卷：72
• 期：19
• 页码：7343 - 7351
• 全文大小：263K
• 年卷期：v.72,no.19(September 14, 2007)
• ISSN：1520-6904

文摘

Callophycoic acids A-H (1-8) and callophycols A and B (9 and 10) were isolated from extracts of theFijian red alga Callophycus serratus, and identified by NMR, X-ray, and mass spectral analyses. Thesenatural products represent four novel carbon skeletons, providing the first examples of diterpene-benzoicacids and diterpene-phenols in macroalgae. Compounds 1-10 exhibited antibacterial, antimalarial, andanticancer activity, although they are less bioactive than diterpene-benzoate macrolides previously isolatedfrom this red alga.