Bioactive Bromophycolides R−U from the Fijian Red Alga Callophycus serratus
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- 作者：An-Shen Lin ; E. Paige Stout ; Jacques Prudhomme ; Karine Le Roch ; Craig R. Fairchild ; Scott G. Franzblau ; William Aalbersberg ; Mark E. Hay ; Julia Kubanek
- 刊名：Journal of Natural Products
- 出版年：2010
- 出版时间：February 26, 2010
- 年：2010
- 卷：73
- 期：2
- 页码：275-278
- 全文大小：110K
- 年卷期：v.73,no.2(February 26, 2010)
- ISSN：1520-6025
文摘
Four new bromophycolides, R−U (1−4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.