Buckwheat Concentrate Reduces Serum Glucose in Streptozotocin-Diabetic Rats

详细信息    查看全文

• 作者：Julianne M. Kawa ; Carla G. Taylor ; and Roman Przybylski
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2003
• 出版时间：December 3, 2003
• 年：2003
• 卷：51
• 期：25
• 页码：7287 - 7291
• 全文大小：97K
• 年卷期：v.51,no.25(December 3, 2003)
• ISSN：1520-5118

文摘

The antihyperglycemic effects of chemically synthesized D-chiro-inositol (D-CI), a component of aninsulin mediator, have been demonstrated in rats. Buckwheat contains relatively high levels of D-CI:thus, it has been proposed as a source of D-CI for reducing serum glucose concentrations in diabetics.The present study evaluates the effects of a buckwheat concentrate, containing D-CI, on hyperglycemiaand glucose tolerance in streptozotocin (STZ) rats. In fed STZ rats, both doses of the buckwheatconcentrate (containing 10 and 20 mg of D-CI/kg of body weight) were effective for lowering serumglucose concentrations by 12-19% at 90 and 120 min after administration. Findings from this studydemonstrate that a buckwheat concentrate is an effective source of D-CI for lowering serum glucoseconcentrations in rats and therefore may be useful in the treatment of diabetes.Keywords: D-chiro-Inositol; buckwheat concentrate; diabetes; streptozotocin rats