Multifunctional Bacteriochlorins from Selective Palladium-Coupling Reactions

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• 作者：Zhanqian Yu ; Marcin Ptaszek
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：July 20, 2012
• 年：2012
• 卷：14
• 期：14
• 页码：3708-3711
• 全文大小：205K
• 年卷期：v.14,no.14(July 20, 2012)
• ISSN：1523-7052

文摘

Nonsymmetrical, multifunctional bacteriochlorin derivatives possessing different substituents at the 尾-pyrrolic positions have been prepared by stepwise, selective functionalization of 3,13-dibromo-5-methoxybacteriochlorin via palladium-coupling reactions. The new derivatives reported here include monovalent bioconjugatable bacteriochlorin, orthogonally protected bacteriochlorin amino acid, and push鈥損ull bacteriochlorins. Taken together, this study provides a route to previously unavailable bacteriochlorin architectures for fundamental studies and diverse applications.