Malabaricone C from Myristica cinnamomea Exhibits Anti-Quorum Sensing Activity

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• 作者：Yee Meng Chong ; Wai Fong Yin ; Chia Yong Ho ; Mohamad Rais Mustafa ; A. Hamid A. Hadi ; Khalijah Awang ; Putri Narrima ; Chong-Lek Koh ; David R. Appleton ; Kok-Gan Chan
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：October 28, 2011
• 年：2011
• 卷：74
• 期：10
• 页码：2261-2264
• 全文大小：710K
• 年卷期：v.74,no.10(October 28, 2011)
• ISSN：1520-6025

文摘

A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.