A 鈥淐lick and Activate鈥?Approach in One-Pot Synthesis of a Triazolyl-Pyridazinone Library

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• 作者：Wenyuan Qian ; David Winternheimer ; Jennifer Allen
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：April 1, 2011
• 年：2011
• 卷：13
• 期：7
• 页码：1682-1685
• 全文大小：734K
• 年卷期：v.13,no.7(April 1, 2011)
• ISSN：1523-7052

文摘

A 鈥渃lick and activate鈥?strategy was designed and executed in a four-component, stepwise condensation that led to a trisubstituted triazolyl-pyridazinone library. This one-pot process included regioselective azide substitution at 2-substituted-4,5-dichloropyridazinones, followed by a Cu(I) catalyzed triazole formation which triggered subsequent nucleophilic substitution at the neighboring position to achieve three points of diversity.