General and Chemoselective Bisphosphonylation of Secondary and Tertiary Amides

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• 作者：Ai-E Wang ; Zong Chang ; Wei-Ting Sun ; Pei-Qiang Huang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：732-735
• 全文大小：305K
• ISSN：1523-7052

文摘

With Tf₂O as the activation reagent, a mild and general method has been developed for the bisphosphonylation of both secondary and tertiary amides. The protocol is highly efficient and chemoselective, and it tolerates a number of sensitive functional groups such as cyano, ester, and aldehyde groups.