Dual Roles of Sulfonyl Hydrazides: A Three-Component Reaction To Construct Fully Substituted Pyrazoles Using TBAI/TBHP

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• 作者：Jie Zhang ; Ying Shao ; Hongxiang Wang ; Qiang Luo ; Jijun Chen ; Dongmei Xu ; Xiaobing Wan
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：June 20, 2014
• 年：2014
• 卷：16
• 期：12
• 页码：3312-3315
• 全文大小：294K
• 年卷期：v.16,no.12(June 20, 2014)
• ISSN：1523-7052

文摘

A mild and rapid approach has been developed for the construction of fully substituted pyrazoles using TBAI as a catalyst and TBHP as an oxidant, in which tosylhydrazide functions as the ring component and sulfonyl precursor. This protocol features a wide substrate scope with a broad range of functional group tolerance, utilizes easily available starting materials, can be scaled-up, and is operationally simple.