Gold Nanoflower@Gelatin Core鈥揝hell Nanoparticles Loaded with Conjugated Polymer Applied for Cellular Imaging
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- 作者：Qianling Cui ; Fang He ; Xiaoyu Wang ; Bihua Xia ; Lidong Li
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2013
- 出版时间：January 9, 2013
- 年：2013
- 卷：5
- 期：1
- 页码：213-219
- 全文大小：412K
- 年卷期：v.5,no.1(January 9, 2013)
- ISSN：1944-8252
文摘
In the present work, a facile one-pot method is designed to fabricate a core鈥搒hell fluorescent nanoparticle (NP) for cellular imaging based on a new cationic conjugated polymer, poly[9,9鈥?bis(6,6鈥?(N,N,N-trimethylaminium)fluorene-2,7-ylenevinylene-co-alt-2,5-dicyano-1,4-phenylene] (PFVCN). Gold nanoflowers (AuNFs) are prepared by a seedless method, in which a gelatin layer formed through a sol鈥揼el phase transition is deposited on the surface of each AuNF. The cationic PFVCN self-assembles onto the negative surface of the resultant (AuNF@Gelatin NPs) driven by electrostatic attraction. An obvious enhancement of fluorescence intensity is observed. The AuNF@Gelatin/PFVCN NPs exhibit excellent cytocompatibility, and their cellular imaging ability is demonstrated when cocultured with HeLa cells. AuNF@Gelatin/PFVCN hybrid NPs are expected to be a desirable material in the field of cellular imaging and biosensing.