Nickel-Catalyzed 伪-Arylation of Zinc Enolates with Polyfluoroarenes via C鈥揊 Bond Activation under Neutral Conditions

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• 作者：Daohong Yu ; Chang-Sheng Wang ; Cheng Yao ; Qilong Shen ; Long Lu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 7, 2014
• 年：2014
• 卷：16
• 期：21
• 页码：5544-5547
• 全文大小：361K
• ISSN：1523-7052

文摘

The first nickel-catalyzed 伪-arylation of 2-(polyfluorophenyl) pyridine with zinc enolates of esters or amides via C鈥揊 bond activation under neutral conditions is described. A variety of functional groups such as ester, amide, ether, and amine were tolerated. This method provides a simple and useful tool to synthesize fluorinated 伪-aryl carboxylic acids and 伪-aryl amides that are important intermediates for drug discovery.