Hypophyllins A–D, Labdane-Type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya “Rosea”Xing-De Wu, Dan Luo, Wen-Chao Tu, Zhen-Tao Deng, Xue-Jiao Chen, Jia Su, Xu Ji, and Qin-Shi Zhaopp 6484–6487Publication Date (Web): December 1, 2016 (Letter)DOI: 10.1021/acs.orglett.6b
文摘
Three rearranged labdane-type diterpenoids, hypophyllins A–C (1–3), and a caged labdane diterpenoid possessing a 8,9-dioxatricyclic[4.2.1.13,7]decane moiety, hypophyllin D (4), as well as two new biogenetically related diterpernoids, hypophyllins E (5) and F (6), were isolated from the aerial parts of Hypoestes phyllostachya “Rosea”. The absolute configurations of 1–4 were determined by X-ray diffraction analysis. The plausible biogenetic pathway for 1–4 was also proposed. Compounds 4 and 5 showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.