Robust Nonenzymatic Hybrid Nanoelectrocatalysts for Signal Amplification toward Ultrasensitive Electrochemical Cytosensing

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• 作者：Tingting Zheng ; Qingfeng Zhang ; Sheng Feng ; Jun-Jie Zhu ; Qian Wang ; Hui Wang
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：February 12, 2014
• 年：2014
• 卷：136
• 期：6
• 页码：2288-2291
• 全文大小：361K
• ISSN：1520-5126

文摘

We have discovered that magnetic Fe₃O₄ nanoparticles exhibit an intrinsic catalytic activity toward the electrochemical reduction of small dye molecules. Metallic nanocages, which act as efficient signal amplifiers, can be attached to the surface of Fe₃O₄ beads to further enhance the catalytic electrochemical signals. The Fe₃O₄@nanocage core鈥搒atellite hybrid nanoparticles show significantly more robust electrocatalytic activities than the enzymatic peroxidase/H₂O₂ system. We have further demonstrated that these nonenzymatic nanoelectrocatalysts can be used as signal-amplifying nanoprobes for ultrasensitive electrochemical cytosensing.