2-Phenoxychromones and Prenylflavonoids from Epimedium koreanum and Their Inhibitory Effects on LPS-Induced Nitric Oxide and Interleukin-1尾 Production

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• 作者：Qinghao Jin ; Chul Lee ; Jin Woo Lee ; Eung Tae Yeon ; Dongho Lee ; Sang Bae Han ; Jin Tae Hong ; Youngsoo Kim ; Mi Kyeong Lee ; Bang Yeon Hwang
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：July 25, 2014
• 年：2014
• 卷：77
• 期：7
• 页码：1724-1728
• 全文大小：252K
• ISSN：1520-6025

文摘

Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5鈥?6) were isolated from the CH₂Cl₂-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC₅₀ values ranging from 16.8 to 49.3 渭M. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1尾 production with IC₅₀ values ranging from 8.6 to 38.9 渭M in RAW 264.7 macrophages.