How Might Qinghaosu (Artemisinin) and Related Compounds Kill the Intraerythrocytic Malaria Parasite? A Chemist's View

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• 作者：Yikang Wu
• 刊名：Accounts of Chemical Research
• 出版年：2002
• 出版时间：May 2002
• 年：2002
• 卷：35
• 期：5
• 页码：255 - 259
• 全文大小：78K
• 年卷期：v.35,no.5(May 2002)
• ISSN：1520-4898

文摘

The antimalarial mechanism of qinghaosu (artemisinin) has beena problem since the late 1970s. During the past decade, severalmolecular level theories were postulated. However, their furtherdevelopment has been very difficult. By looking into the QHScleavage process and all possible reaction paths available to theresulting transient radicals, the present commentary reveals thosemajor hidden problems with the existing theories and tries toidentify some essential features of the parasiticidal events that maytake place within the intraerythrocytic malaria parasite. A seeminglymore reasonable theory is also introduced.