Antineoplastic Agents. 573. Isolation and Structure of Papilistatin from the Papilionid Butterfly Byasa polyeuctes termessa

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• 作者：George R. Pettit ; Qinghua Ye ; Delbert L. Herald ; Fiona Hogan ; Robin K. Pettit
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：February 26, 2010
• 年：2010
• 卷：73
• 期：2
• 页码：164-166
• 全文大小：98K
• 年卷期：v.73,no.2(February 26, 2010)
• ISSN：1520-6025

文摘

Bioassay-guided separation of an extract of the wings from a Taiwan butterfly, Byasa polyeuctes termessa, allowed isolation of a new cancer cell growth inhibitor designated papilistatin (1a). The structure was determined by analysis of 1D and 2D NMR spectra and by HRMS. Against a panel of six human and the murine P388 leukemia cancer cell lines, papilistatin exhibited cancer cell growth inhibition with GI₅₀’s of 0.093−3.5 μg/mL. Papilistatin was also found to have antibacterial activity.