Rhodium-Catalyzed Enantioselective Hydrogenation of Tetrasubstituted 伪-Acetoxy 尾-Enamido Esters: A New Approach to Chiral 伪-Hydroxyl-尾-amino Acid Derivatives
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- 作者：Qingli Wang ; Wenhua Huang ; Haoquan Yuan ; Qin Cai ; Liming Chen ; Hui Lv ; Xumu Zhang
- 刊名：Journal of the American Chemical Society
- 出版年：2014
- 出版时间：November 19, 2014
- 年：2014
- 卷：136
- 期：46
- 页码：16120-16123
- 全文大小：336K
- ISSN：1520-5126
文摘
Asymmetric hydrogenation of tetrasubtitued 伪-acetoxy 尾-enamido esters with rhodium catalysts based on chiral diphosphine ligands provides an efficient and concise route to the synthesis of chiral 伪-hydroxyl-尾-amino acid derivatives in excellent enantioselectivities. The products are valuable chiral building blocks in many biologically active compounds and have important applications in organic synthesis.