All-Aqueous Electrosprayed Emulsion for Templated Fabrication of Cytocompatible Microcapsules

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• 作者：Yang Song ; Yau Kei Chan ; Qingming Ma ; Zhou Liu ; Ho Cheung Shum
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：July 1, 2015
• 年：2015
• 卷：7
• 期：25
• 页码：13925-13933
• 全文大小：532K
• ISSN：1944-8252

文摘

Encapsulation of biomolecules and cells in hydrogel capsules via emulsion templating frequently induces an irreversible loss of bioactivity, because of the use of nonaqueous solvents. Here, we introduce an all-aqueous electrospray (AAE) approach to generate aqueous two-phase emulsion droplets, and we use them as templates to fabricate microcapsules with preserved cell viability. The approach allows formation of monodisperse microparticles with tunable sizes, variable compositions, and interior architectures in a mild gelation process. This technique potentially benefits a variety of new biomedical applications, such as delivery of bioactive proteins, transplantation of living cells, and assembly of cell-mimicking structures.