A New Prodrug-Derived Ratiometric Fluorescent Probe for Hypoxia: High Selectivity of Nitroreductase and Imaging in Tumor Cell

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• 作者：Lei Cui ; Ye Zhong ; Weiping Zhu ; Yufang Xu ; Qingshan Du ; Xin Wang ; Xuhong Qian ; Yi Xiao
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：March 4, 2011
• 年：2011
• 卷：13
• 期：5
• 页码：928-931
• 全文大小：752K
• 年卷期：v.13,no.5(March 4, 2011)
• ISSN：1523-7052

文摘

Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescent ratiometric probe for hypoxia in solid tumors.