Biomolecule-Assisted Synthesis of Water-Soluble Silver Nanoparticles and Their Biomedical Applications

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• 作者：Qingzhi Wu ; Huaqiang Cao ; Qiuying Luan ; Jiyong Zhang ; Zhao Wang ; Jamie H. Warner ; Andrew A. R. Watt
• 刊名：Inorganic Chemistry
• 出版年：2008
• 出版时间：July 7, 2008
• 年：2008
• 卷：47
• 期：13
• 页码：5882 - 5888
• 全文大小：7880K
• 年卷期：v.47,no.13(July 7, 2008)
• ISSN：1520-510X

文摘

The application of nanoparticles in the biomedical field is an exciting interdisciplinary research area in current materials science. In the present study, size-tunable and water-soluble noble metal silver nanoparticles (Ag NPs) have been successfully synthesized with the assistance of glutathione (GSH). The as-synthesized Ag NPs are ready to bind covalently with a model protein (bovine serum albumin) in mild conditions. The optical property of surface-modifiable Ag NPs was extremely sensitive to their size and the surface modification, suggesting a potential in the biomedical analysis and detection. Furthermore, Ag NPs with an average diameter of ca. 6 nm effectively suppress the proliferation of human leukemic K562 cells in the dose- and time-dependent manners, suggesting the promising potential of Ag NPs in cancer therapy.