Structure鈥揊unction Relationships of a Tertiary Amine-Based Polycarboxybetaine
详细信息 查看全文
- 作者：Chen-Jung Lee ; Haiyan Wu ; Qiong Tang ; Bin Cao ; Huifeng Wang ; Hongbo Cong ; Jiang Zhe ; Fujian Xu ; Gang Cheng
- 刊名：Langmuir
- 出版年：2015
- 出版时间：September 15, 2015
- 年：2015
- 卷：31
- 期：36
- 页码：9965-9972
- 全文大小：404K
- ISSN：1520-5827
文摘
Zwitterionic polycarboxybetaine (PCB) materials have attracted noticeable interest for biomedical applications, such as wound healing/tissue engineering, medical implants, and biosensors, due to their excellent antifouling properties and design flexibility. Antifouling materials with buffering capability are particularly useful for many biomedical applications. In this work, an integrated zwitterionic polymeric material, poly(2-((2-hydroxyethyl)(2-methacrylamidoethyl)ammonio)acetate) (PCBMAA-1T), was synthesized to carry desired properties (antifouling, switchability and buffering capability). A tertiary amine was used to replace quaternary ammonium as the cation to endow the materials with buffering capability under neutral pH. Through this study, a better understanding on the structure鈥損roperty relationship of zwitterionic materials was obtained. The tertiary amine cation does not compromise antifouling properties of zwitterionic materials. The amount of adsorbed proteins on PCBMAA-1T polymer brushes is less than 0.8 ng/cm2 for fibrinogen and 0.3 ng/cm2 (detection limit of the surface plasmon resonance sensor) for both undiluted blood plasma and serum. It is found that the tertiary amine is favorable to obtain good lactone ring stability in switchable PCB materials. Titration study showed that PCBMAA-1T could resist pH changes under both acidic (pH 1鈥?) and neutral/basic (pH 7鈥?) conditions. To the best of our knowledge, such an all-in-one material has not been reported. We believe this material might be potentially used for a variety of applications, including tissue engineering, chronic wound healing and medical device coating.