Antibacterial Adhesion of Borneol-Based Polymer via Surface Chiral Stereochemistry
详细信息 查看全文
- 作者：Lingqiong Luo ; Guofeng Li ; Di Luan ; Qipeng Yuan ; Yen Wei ; Xing Wang
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2014
- 出版时间：November 12, 2014
- 年：2014
- 卷：6
- 期：21
- 页码：19371-19377
- 全文大小：375K
- ISSN：1944-8252
文摘
During its adhesion on external surfaces, a cell exhibits obvious inclination to different molecular chirality, which encourages us to develop a new type of antibacterial material catering to the 鈥渃hiral taste鈥?of bacteria. On the basis of the natural product borneol (a camphane-type bicyclic monoterpene), a series of borneol-based polymer, polyborneolacrylate (PBA), was successfully prepared and showed superior antibacterial adhesion properties resulting from the borneol isomers on material surface. The results of this study reveal that bacteria simply dislike this type of stubborn surface of PBA, and the PBA surface stereochemistry contributes to the interfacial antibacterial activities. The PBA polymers were evaluated as noncytotoxic and can be simply synthesized, demonstrating their great potential for biomedical applications.