Dedifferentiation of Lineage-Committed Cells by a Small Molecule

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• 作者：Shuibing Chen ; Qisheng Zhang ; Xu Wu ; Peter G. Schultz ; and Sheng Ding
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：January 21, 2004
• 年：2004
• 卷：126
• 期：2
• 页码：410 - 411
• 全文大小：227K
• 年卷期：v.126,no.2(January 21, 2004)
• ISSN：1520-5126

文摘

Combinatorial libraries were screened for molecules that induce mouse myogenic lineage committed cells to dedifferentiate in vitro. A 2,6-disubstituted purine, reversine, was discovered that induces lineage reversal of C2C12 cells to become multipotent progenitor cells which can redifferentiate into osteoblasts and adipocytes. This and other such molecules are likely to provide new insights into the molecular mechanisms that control cellular dedifferentiation and may ultimately be useful to in vivo stem cell biology and therapy.