Fe-Catalyzed Double Cross-Dehydrogenative Coupling of 1,3-Dicarbonyl Compounds and Arylmethanes

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• 作者：Kai Yang ; Qiuling Song
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：548-551
• 全文大小：338K
• ISSN：1523-7052

文摘

Fe-catalyzed tandem cross-dehydrogenative coupling of the methyl group in arylmethanes with 1,3-dicarbonyl compounds has been developed. The reaction affords one new C(sp³)鈥揅(sp²) bond and one new C(sp³)鈥揅(sp³) bond in a one-pot protocol. Further study suggests that this reaction might start with a Friedel鈥揅rafts-type reaction (cross-dehydrogenative arylation) followed by cross-dehydrogenative coupling with an activated methylene group under mild oxidative conditions.