Copper-Catalyzed Direct Trifluoromethylation of Propiolates: Construction of Trifluoromethylated Coumarins

详细信息    查看全文

• 作者：Yuewen Li ; Yuan Lu ; Guanyinsheng Qiu ; Qiuping Ding
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 15, 2014
• 年：2014
• 卷：16
• 期：16
• 页码：4240-4243
• 全文大小：297K
• ISSN：1523-7052

文摘

A novel copper-catalyzed direct trifluoromethylation of internal alkynes was developed, obtaining a series of trifluoromethylated coumarins in good yields. The cyclization was proposed to proceed via a radical mechanism under copper-catalyzed conditions with good functional group tolerance.