Metal鈥揙rganic Frameworks with Phosphotungstate Incorporated for Hydrolytic Cleavage of a DNA-Model Phosphodiester
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- 作者：Qiuxia Han ; Lejie Zhang ; Cheng He ; Jiangyang Niu ; Chunying Duan
- 刊名：Inorganic Chemistry
- 出版年：2012
- 出版时间：May 7, 2012
- 年：2012
- 卷：51
- 期：9
- 页码：5118-5127
- 全文大小：609K
- 年卷期：v.51,no.9(May 7, 2012)
- ISSN：1520-510X
文摘
Five phosphotungstate-incorporated metal鈥搊rganic frameworks {[Eu4(dpdo)9(H2O)16PW12O40]}(PW12O40)2路(dpdo)3路Cl3 (1); {ZnNa2(渭-OH)(dpdo)4(H2O)4[PW12O40]}路3H2O (2); {Zn3(dpdo)7}[PW12O40]2路3H2O (3); and [Ln2H(渭-O)2(dpdo)4(H2O)2][PW12O40]路3H2O (Ln = Ho for 4 and Yb for 5) (dpdo = 4,4鈥?bipyridine-N,N鈥?dioxide) have been synthesized through a one-step hydrothermal reaction and characterized by elemental analyses, infrared (IR) spectroscopy, photoluminescence, and single-crystal X-ray diffraction (XRD). The structural analyses indicate that 1鈥?b>5 display diversity structure from one-dimensional (1D) to three-dimensional (3D) series of hybrids. Kinetic experiments for the hydrolytic cleavage of DNA-model phosphodiester BNPP (bis(p-nitrophenyl)phosphate) were followed spectrophotometrically for the absorbance increase at 400 nm in EPPS (4-(2-hydroxyethyl)piperazine-1-propane sulfonic acid) buffer solution, because of the formation of p-nitrophenoxide with 1鈥?b>5 under conditions of pH 4.0 and 50 掳C. Ultraviolet (UV) spectroscopy indicate that the cleavage of the phosphodiester bond proceeds with the pseudo-first-order rate constant in the range of 10鈥?鈥?0鈥? s鈥?, giving an inorganic phosphate and p-nitrophenol as the final products of hydrolysis. The results demonstrate that 1鈥?b>5 have good catalytic activity and reusability for hydrolytic cleavage of BNPP.