Blood and Hair Manganese Concentrations in Pregnant Women from the Infants鈥?Environmental Health Study (ISA) in Costa Rica

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• 作者：Ana M. Mora ; Berna van Wendel de Joode ; Donna Mergler ; Leonel C贸rdoba ; Camilo Cano ; Rosario Quesada ; Donald R. Smith ; Jos茅 A. Menezes-Filho ; Thomas Lundh ; Christian H. Lindh ; Asa Bradman ; Brenda Eskenazi
• 刊名：Environmental Science & Technology
• 出版年：2014
• 出版时间：March 18, 2014
• 年：2014
• 卷：48
• 期：6
• 页码：3467-3476
• 全文大小：284K
• 年卷期：v.48,no.6(March 18, 2014)
• ISSN：1520-5851

文摘

Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associated with these biomarkers. Mean blood Mn and geometric mean hair Mn concentrations were 24.4 渭g/L (8.9鈥?6.3) and 1.8 渭g/g (0.05鈥?3.3), respectively. Blood Mn concentrations were positively associated with gestational age at sampling (尾 = 0.2; 95% CI: 0.1 to 0.2), number of household members (尾 = 0.4; 95% CI: 0.1 to 0.6), and living in a house made of permeable and difficult-to-clean materials (尾 = 2.6; 95% CI: 1.3 to 4.0); and inversely related to smoking (尾 = 鈭?.1; 95% CI: 鈭?.8 to 鈭?.3). Hair Mn concentrations were inversely associated with gestational age at sampling (% change = 0.8; 95% CI: 鈭?.6 to 0.0); and positively associated with living within 50 m of a plantation (% change = 42.1; 95% CI: 14.2 to 76.9) and Mn concentrations in drinking water (% change = 17.5; 95% CI: 12.2 to 22.8). Our findings suggest that pregnant women living near banana plantations aerially sprayed with mancozeb may be environmentally exposed to Mn.