Permission to Enter Cell by Shape: Nanodisk vs Nanosphere
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- 作者：Yi Zhang ; Samuel Tekobo ; Ying Tu ; Qunfang Zhou ; Xinlong Jin ; Sergey A. Dergunov ; Eugene Pinkhassik ; Bing Yan
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2012
- 出版时间：August 22, 2012
- 年：2012
- 卷：4
- 期：8
- 页码：4099-4105
- 全文大小：397K
- 年卷期：v.4,no.8(August 22, 2012)
- ISSN：1944-8252
文摘
Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.