Synthesis and Spectroscopic Properties of a Prototype Single Molecule Dual Imaging Agent Comprising a Heterobimetallic Rhenium-Gadolinium Complex

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• 作者：Thelma Koullourou ; Louise S. Natrajan ; Hiren Bhavsar ; Simon J.A. Pope ; Jianghua Feng ; Johanna Narvainen ; Rachel Shaw ; Emma Scales ; Risto Kauppinen ; Alan M. Kenwright ; Stephen Faulkner
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：February 20, 2008
• 年：2008
• 卷：130
• 期：7
• 页码：2178 - 2179
• 全文大小：48K
• 年卷期：v.130,no.7(February 20, 2008)
• ISSN：1520-5126

文摘

A luminescent d-f hybrid containing a [Re(bpy)(Ar)(CO)₃]⁺ chromophore and a gadolinium ion bound in a DO3A-derived binding pocket has been prepared. This complex combines long-lived luminescence from the ³MLCT state of the transition metal chromophore with high relaxivity, making it suitable for MRI imaging and luminescence imaging. The analogous complex containing ytterbium exhibits sensitized emission from both the ytterbium center and long-lived emission from the ³MLCT state.