Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy
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- 作者：Sijumon Kunjachan ; Alexandre Detappe ; Rajiv Kumar ; Thomas Ireland ; Lisa Cameron ; Douglas E. Biancur ; Vincent Motto-Ros ; Lucie Sancey ; Srinivas Sridhar ; G. Mike Makrigiorgos ; Ross I. Berbeco
- 刊名：Nano Letters
- 出版年：2015
- 出版时间：November 11, 2015
- 年：2015
- 卷：15
- 期：11
- 页码：7488-7496
- 全文大小：810K
- ISSN：1530-6992
文摘
More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.