Macrocyclic Chiral Receptors toward Enantioselective Recognition of Naproxen

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• 作者：Silvia Gonz&aacute ; lez ; Rafael Pel&aacute ; ez ; Francisca Sanz ; M Belé ; n Jimé ; nez ; Joaquí ; n R. Mor&aacute ; n ; M Cruz Caballero
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：October 12, 2006
• 年：2006
• 卷：8
• 期：21
• 页码：4679 - 4682
• 全文大小：114K
• 年卷期：v.8,no.21(October 12, 2006)
• ISSN：1523-7052

文摘

A macrocyclic receptor based on a bischromenylurea and an ,'-(o,o'-dialkyl)diphenyl-p-xylylenediamine spacer provides a C₂ chiral cavityto associate carboxylates by H-bonds. The extent of the selectivity obtained for the racemic receptor 2 and enantiomerically pure (S)-naproxenis 7.2:1. Steric repulsions close to the cavity are decisive for the chiral selectivity.