Regio- and Enantioselective Catalytic Cyclization of Pyrroles onto N-Acyliminium Ions

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• 作者：Izzat T. Raheem ; Parvinder S. Thiara ; Eric N. Jacobsen
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：April 17, 2008
• 年：2008
• 卷：10
• 期：8
• 页码：1577 - 1580
• 全文大小：137K
• 年卷期：v.10,no.8(April 17, 2008)
• ISSN：1523-7052

文摘

The regio- and enantioselective cyclization of pyrroles onto N-acyliminium ions generated in situ from hydroxylactams is reported. Modest toexcellent ee's and yields are obtained in these novel Pictet-Spengler-type reactions with a chiral thiourea-pyrrole catalyst. Useful synthetictransformations of the versatile pyrroloindolizidinone and pyrroloquinolizidinone products are presented.