Xanalteric Acids I and II and Related Phenolic Compounds from an Endophytic Alternaria sp. Isolated from the Mangrove Plant Sonneratia alba
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- 作者：Julia Kjer ; Victor Wray ; RuAngelie Edrada-Ebel ; Rainer Ebel ; Alexander Pretsch ; Wenhan Lin ; Peter Proksch
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：November 30, 2009
- 年：2009
- 卷：72
- 期：11
- 页码：2053-2057
- 全文大小：125K
- 年卷期：v.72,no.11(November 30, 2009)
- ISSN：1520-6025
文摘
Two new 10-oxo-10H-phenaleno[1,2,3-de]chromene-2-carboxylic acids, xanalteric acids I (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungus Alternaria sp., isolated from the mangrove plant Sonneratia alba collected in China. The metabolites were confirmed to be of fungal origin, and the structures of the new natural products were unambiguously elucidated on the basis of extensive one- and two-dimensional NMR spectroscopic studies and mass spectrometric analysis. The two new compounds 1 and 2 exhibited weak antibiotic activity against multidrug-resistant Staphylococcus aureus. Altenusin (3) displayed broad antimicrobial activity against several additional multidrug-resistant bacterial and fungal strains.