Cooperative Multicatalytic System for the One-Pot Synthesis of Octahydrospiro-尾-carbolines

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• 作者：B. V. Subba Reddy ; M. Rajashekhar Reddy ; Suresh Yarlagadda ; C. Ravikumar Reddy ; G. Ravi Kumar ; J. S. Yadav ; B. Sridhar
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：September 4, 2015
• 年：2015
• 卷：80
• 期：17
• 页码：8807-8814
• 全文大小：380K
• ISSN：1520-6904

文摘

A domino cyclization of 3-((3-(2-aminophenyl)prop-2-ynylamino)methyl)but-3-en-1-ol with aldehydes has been accomplished employing 5 mol % of the Ph₃PAuCl/AgSbF₆/In(OTf)₃ system to afford the corresponding octahydrospiro[pyran-4,4鈥?pyrido[3,4-b]indole] derivatives in good yields with high selectivity. This is the first report on the synthesis of spiro-尾-carbolines through a multicatalytic cascade process.