Synthesis and Antiplasmodial and Antimycobacterial Evaluation of New Nitroimidazole and Nitroimidazooxazine Derivatives
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- 作者：Matshawandile Tukulula ; Rajni-Kant Sharma ; Ma茂a Meurillon ; Aman Mahajan ; Krupa Naran ; Digby Warner ; Jianxing Huang ; Belew Mekonnen ; Kelly Chibale
- 刊名：ACS Medicinal Chemistry Letters
- 出版年：2013
- 出版时间：January 10, 2013
- 年：2013
- 卷：4
- 期：1
- 页码：128-131
- 全文大小：267K
- 年卷期：v.4,no.1(January 10, 2013)
- ISSN：1948-5875
文摘
The synthesis and antiplasmodial and antimycobacterial evaluation of two new series of nitroimidazole and nitroimidazooxazine derivatives is described. The majority of these compounds, especially hybrids 9d, 9f, and 14b, exhibited potent activity against the chloroquine-resistant K1 strain of Plasmodium falciparum. Furthermore, a notable number from the tetrazole series were significantly more active against M. tuberculosis than kanamycin, a standard TB drug.