Palladium-Promoted [2 + 2 + 2] Cocyclization of Arynes and Unsymmetrical Conjugated Dienes: Synthesis of Justicidin B and Retrojusticidin B

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• 作者：Ramesh M. Patel ; Narshinha P. Argade
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：January 4, 2013
• 年：2013
• 卷：15
• 期：1
• 页码：14-17
• 全文大小：296K
• 年卷期：v.15,no.1(January 4, 2013)
• ISSN：1523-7052

文摘

A facile synthesis of natural and unnatural arylnaphthalenes has been demonstrated via the unprecedented palladium-promoted [2 + 2 + 2] cocyclization of arynes and unsymmetrical conjugated dienes using the N-heterocyclic carbene as a ligand. The unsymmetrical dienes used herein are actually 伪-coupled acrylate鈥揷innamate combinations bearing two 尾-positive carbons and follow the key [2 + 2 + 2] cocyclization pathway.