Synthesis of Novel Nucleoside Analogues Built on a Bicyclo[4.1.0]heptane Scaffold

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• 作者：Beatriz Dom谋虂nguez-P茅rez ; 脡ric Ferrer ; Marta Figueredo ; Jean-Didier Mar茅chal ; Jan Balzarini ; Ramon Alib茅s ; F茅lix Busqu茅
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：October 2, 2015
• 年：2015
• 卷：80
• 期：19
• 页码：9495-9505
• 全文大小：514K
• ISSN：1520-6904

文摘

A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein鈥搇igand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione.