Synthesis of Water-Soluble Phosphine Oxides by Pd/C-Catalyzed P鈥揅 Coupling in Water

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• 作者：Stephan M. Rummelt ; Marco Ranocchiari ; Jeroen A. van Bokhoven
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：April 20, 2012
• 年：2012
• 卷：14
• 期：8
• 页码：2188-2190
• 全文大小：170K
• 年卷期：v.14,no.8(April 20, 2012)
• ISSN：1523-7052

文摘

Cross-coupling between diphenylphosphine oxide and halogenated benzoic acids catalyzed by Pd/C in water is a green, simple, and fast protocol to obtain water-soluble tertiary phosphine oxides without the addition of ligands and additives. Low reaction times and microwave irradiation make this method general and excellent for laboratory and large-scale synthesis without the need to use organic solvents in reactions and workup.