文摘
Bioassay-guided phytochemical investigation of Zygogynum calothyrsum using the human colon carcinoma cell lines COLO205 and KM12 led to the isolation of three new drimane-type sesquiterpenoids, 1尾-p-hydroxy-E-cinnamoyldrimeninol (1), 1尾-p-hydroxy-E-cinnamoyl-5伪-hydroxydrimeninol (2), and methyl ether of 1尾-p-hydroxy-E-cinnamoyl-12伪-methoxydrimeninol (3). Also isolated was the known 1尾-p-coumaroyloxypolygodial (4) together with two new tetralones, 3鈥?deoxyisozygolone A (5) and calothyrlone A (9), three known tetralones, isozygolone A (6), zygolone A (7), and 4鈥?O-methylzygolone A (8), and a known cinnamolide (10). Compounds 1, 7, and 8 demonstrated higher cytotoxicity against COLO205 (GI50 18, 17, and 11 渭M, respectively) and KM12 (GI50 14, 14, and 17 渭M, respectively) than the other compounds.