Copper-Catalyzed Inter- and Intramolecular C鈥揘 Bond Formation: Synthesis of Benzimidazole-Fused Heterocycles

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• 作者：Sk. Rasheed ; D. Nageswar Rao ; Parthasarathi Das
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：September 18, 2015
• 年：2015
• 卷：80
• 期：18
• 页码：9321-9327
• 全文大小：455K
• ISSN：1520-6904

文摘

A Cu (II)-catalyzed, inter/intramolecular C鈥揘 bond formation for the synthesis of various benzimidazole-fused heterocycles in a concise manner has been reported. The robustness of this reaction is demonstrated by the synthesis of a series of benzimidazole-fused heteroaromatics (e.g., pyrido[1,2-a] benzimidazole, benzimidazo[1,2-a]quinolines, benzimidazo [1,2-a]pyrazine, benzo[4,5] imidazo[2,1-b]thiazoles) directly from 2-aminoheteroarenens and 2-iodoarylboronic acids in one-pot. The novel cascade protocol for C鈥揘 bond formation operates via unique combination of Chan鈥揕am type coupling followed by Ullmann-type reaction.